Medicinal Chemistry – II All Unit Notes

Bachelor of Pharmacy (B.Pharma)
Medicinal Chemistry – II { BP501T }
All Unit Notes in One PDF

Unit 1
Antihistaminic agents : Histamine, receptors and their distribution in the
humanbody
H1–antagonists :
Diphenhydramine hydrochloride, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride, Phenidamine tartarate, Promethazine hydrochloride*,
Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate,
Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium
H2-antagonists : Cimetidine*, Famotidine, Ranitidin.
Gastric Proton pump inhibitors : Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole
Anti-neoplastic agents :
Alkylating agents : Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa
Antimetabolites : Mercaptopurine, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine
Antibiotics : Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin
Plant products : Etoposide, Vinblastinsulphate, Vincristin sulphate
Miscellaneous : Cisplatin, Mitotane.

Unit 2
Anti-anginal :
Vasodilators : Amylnitrite, Nitroglycerin, Pentaerythritol tetranitrate, Isosorbide dinitrite, Dipyridamole.
Calcium channel blockers : Verapamil, Bepridil hydrochloride, Diltiazem
hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
Diuretics:
Carbonic anhydrase inhibitors : Acetazolamide, Methazolamide, Dichlorphenamide.
Thiazides : Chlorthiazide, Hydrochlorothiazide, Hydroflumethiazide,
Cyclothiazide,
Loop diuretics : Furosemide*,Bumetanide, Ethacrynicacid.
Potassiumsparing
Diuretics : Spironolactone, Triamterene, Amiloride.
Osmotic Diuretics : Mannitol
Anti-hypertensive Agents : Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,*Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.

Unit 3
Anti-arrhythmic Drugs : Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.
Anti-hyperlipidemic agents : Clofibrate, Lovastatin, Cholesteramine and
Cholestipol
Coagulant & Anticoagulants : Menadione, Acetomenadione, Warfarin*,
Anisindione, clopidogrel
Drugs used in Congestive Heart Failure : Digoxin, Digitoxin, Nesiritide,
Bosentan, Tezosentan.

Unit 4
Drugs acting on Endocrine system
Nomenclature, Stereochemistry and metabolism of steroids
Sex hormones : Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethylstilbestrol.
Drugs for erectile dysfunction : Sildenafil, Tadalafil.
Oral contraceptives : Mifepristone, Norgestril, Levonorgestrol
Corticosteroids : Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone
Thyroid and antithyroid drugs : L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole.

Unit 5
Anti diabetic agents:
Insulin and its preparations
Sulfonyl ureas : Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride.
Biguanides : Metformin.
Thiazolidinediones : Pioglitazone, Rosiglitazone.
Meglitinides : Repaglinide, Nateglinide.
Glucosidase inhibitors : Acrabose,Voglibose.
Local Anesthetics : SAR of Local anesthetics
Benzoic Acid derivatives : Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine.
Amino Benzoic acid derivatives : Benzocaine, Butamben, Procaine, Butacaine, Propoxycaine, Tetracaine, Benoxinate.
Lidocaine/Anilide derivatives : Lignocaine, Mepivacaine, Prilocaine, Etidocaine.
Miscellaneous : Phenacaine, Diperodon, Dibucaine.*